Calcium Signaling Toolkit
Current progress (77% complete) on categorising the calcium toolkit, will eventually be a proper database.
Work on the calcium toolkit so far. The data is quite rough and ready and needs to be made more machine readable, though it's not too bad if you just ignore the Notes field. calcium-toolkit.csv last updated 22nd July 2009.
| ID# | UniProt Accession | Group | Name | Type | Gene | Superfamily | Family | Domains | RefSeq | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | P11229, P08172, P20309 | G-Protein receptor | Muscarinic receptor M1-3 | Protein Family | CHRM1, CHRM2, CHRM3 | Family A G protein-coupled receptor-like | Rhodopsin-like | Rhodopsin | NM_000738, NM_001006630, NM_000740 | http://en.wikipedia.org/wiki/Muscarinic_acetylcholine_receptor Found in neurones | ||
| 2 | P35348, P35368 | G-Protein receptor | Adrenoceptors (α1A–C) | Protein | ADRA1A, ADRA1B | RNA bacteriophage capsid protein, Family A G protein-coupled receptor-like | RNA bacteriophage capsid protein, Rhodopsin-like | MS2 virus coat protein, GA coat protein, fr coat protein, Qbeta coat protein, PP7 coat protein, Rhodopsin | Adrenoceptor α1C comes up as the same as α1A when searching UniProt? | |||
| 3 | P30556 | G-Protein receptor | Angiotensin receptor AT1 | Protein | AGTR1 | Family A G protein-coupled receptor-like | Rhodopsin-like | Rhodopsin | NM_000685 | http://en.wikipedia.org/wiki/Angiotensin_II_receptor_type_1 | ||
| 4 | P28336 | G-Protein receptor | Bombesin receptor BRS-1 | Protein | NMBR | Family A G protein-coupled receptor-like | Rhodopsin-like | Rhodopsin | NM_002511 | Neuromedin B receptor | ||
| 5 | P30550 | G-Protein receptor | Bombesin receptors BRS-2 | Protein | GRPR | Family A G protein-coupled receptor-like | Rhodopsin-like | Rhodopsin | ||||
| 6 | P46663 | G-Protein receptor | Bradykinin receptor B1 | Protein | BDKRB1 | Family A G protein-coupled receptor-like | Rhodopsin-like | Rhodopsin | NM_000710 | Data for human but also specified for mouse with uniprot ID Q0VBD7 and refseq ID NP_031565 | ||
| 7 | P30411 | G-Protein receptor | Bradykinin receptor B2 | Protein | BDKRB2 | Family A G protein-coupled receptor-like | Rhodopsin-like | Rhodopsin | NM_000623 | Data for human but also specified for mouse with uniprot ID P32299 and refseq ID NP_033877 | ||
| 8 | P32238 | G-Protein receptor | Cholecystokinin receptor CCK1 | Protein Family | CCKAR | Family A G protein-coupled receptor-like | Rhodopsin-like | Rhodopsin | NM_000730 | 50% Homologous to CCK2 | ||
| 9 | P32239 | G-Protein receptor | Cholecystokinin receptor CCK2 | Protein Family | CCKBR | Family A G protein-coupled receptor-like | Rhodopsin-like | Rhodopsin | NM_176875 | |||
| 10 | P25101 | G-Protein receptor | Endothelin receptor ETA | Protein | EDNRA | Family A G protein-coupled receptor-like | Rhodopsin-like | Rhodopsin | NM_001957 | Mouse uniprot ID Q61614 and refseq ID NM_010332 | ||
| 11 | P24530 | G-Protein receptor | Endothelin receptor ETB | Protein | EDNRB | Family A G protein-coupled receptor-like | Rhodopsin-like | Rhodopsin | NM_000115 | Mouse uniprot ID Q8K1V9 and refseq ID NM_007904. Activates a phosphatidylinoitol-calcium second messenger system. ET1-3 peptides bind. | ||
| 12 | Q13255, P41594 | G-Protein receptor | Metabotropic glutamate receptors (mGlu1, mGlu5) | Protein Family | GRM1, GRM5 | Periplasmic binding protein-like I | L-arabinose binding protein-like | D-ribose-binding protein, L-arabinose-binding protein, D-allose-binding protein, Galactose/glucose-binding protein, Amide receptor/negative regulator of the amidase operon (AmiC), Quorum-sensing signal (autoinducer-2) binding protein LuxP, Purine repressor (PurR), C-terminal domain, Lac-repressor (lacR) core (C-terminal domain), Trehalose repressor, C-terminal domain, Leucine-,isoleucine-,valine-binding (LIV) protein, Leucine-binding protein, Hormone binding domain of the atrial natriuretic peptide receptor, Metabotropic glutamate receptor subtype 1, AI-2 receptor LsrB, Glucose-resistance amylase regulator CcpA, C-terminal domain, Amide receptor/negative regulator of the amidase operon (AmiC), Quorum-sensing signal (autoinducer-2) binding protein LuxP, Purine repressor (PurR), C-terminal domain, Lac-repressor (lacR) core (C-terminal domain), Leucine-,isoleucine-,valine-binding (LIV) protein | ||||
| 13 | P22888 | G-Protein receptor | Luteinizing receptor (LSH) | Protein | LHCGR | L domain-like | Ngr ectodomain-like | von Willebrand factor binding domain of glycoprotein Ib alpha, Reticulon 4 receptor (Nogo-66 receptor, Ngr), Slit, Decorin, High affinity nerve growth factor receptor, N-terminal domain | ||||
| 14 | P35367 | G-Protein receptor | Histamine receptor (H1) | Protein | HRH1 | Family A G protein-coupled receptor-like | Rhodopsin-like | Rhodopsin | ||||
| 15 | P28223, P41595, P28335 | G-Protein receptor | 5-Hydroxytryptamine receptors (5-HT2A, 5-HT2B, 5-HT2C) | Protein Family | HTR2A, HTR2B, HTR2C | Family A G protein-coupled receptor-like | Rhodopsin-like | Rhodopsin | ||||
| 16 | Q15722 | Q9Y271, Q9NS75 | G-Protein receptor | Leukotrine receptors (BLT, CysLT1, CysLT2) | Protein Family | LTB4R | CYSLTR1, CYSLTR2 | Family A G protein-coupled receptor-like | Rhodopsin-like | Rhodopsin | ||||
| 17 | P30989 | G-Protein receptor | Neurotensin receptor (NTS1) | Protein | NTSR1 | Family A G protein-coupled receptor-like | Rhodopsin-like | Rhodopsin | ||||
| 18 | P30559 | G-Protein receptor | Oxytocin receptor (OT) | Protein | OXTR | Family A G protein-coupled receptor-like | Rhodopsin-like | Rhodopsin | ||||
| 19 | P41180 | G-Protein receptor | Extracellular Ca2+-sensing receptor (CaR) | Protein | CASR | Periplasmic binding protein-like I | L-arabinose binding protein-like | D-ribose-binding protein, L-arabinose-binding protein, D-allose-binding protein, Galactose/glucose-binding protein, Amide receptor/negative regulator of the amidase operon (AmiC), Quorum-sensing signal (autoinducer-2) binding protein LuxP, Purine repressor (PurR), C-terminal domain, Lac-repressor (lacR) core (C-terminal domain), Trehalose repressor, C-terminal domain, Leucine-,isoleucine-,valine-binding (LIV) protein, Leucine-binding protein, Hormone binding domain of the atrial natriuretic peptide receptor, Metabotropic glutamate receptor subtype 1, AI-2 receptor LsrB, Glucose-resistance amylase regulator CcpA, C-terminal domain | ||||
| 20 | P43088 | G-Protein receptor | Prostanoid receptor (PGF2α) | Protein | PTGFR | Family A G protein-coupled receptor-like | Rhodopsin-like | Rhodopsin | ||||
| 21 | P25116 | G-Protein receptor | Thrombin receptor (PAR1) | Protein | F2R | Family A G protein-coupled receptor-like | Rhodopsin-like | Rhodopsin | ||||
| 22 | P25103 | G-Protein receptor | Substance P receptor (NK1) | Protein | TACR1 | Family A G protein-coupled receptor-like | Rhodopsin-like | Rhodopsin | ||||
| 23 | P21452 | G-Protein receptor | Substance K receptor (NK2) | Protein | TACR2 | Family A G protein-coupled receptor-like | Rhodopsin-like | Rhodopsin | ||||
| 24 | P29371 | G-Protein receptor | Substance B receptor (NK3) | Protein | TACR3 | Family A G protein-coupled receptor-like | Rhodopsin-like | Rhodopsin | ||||
| 25 | P34981 | G-Protein receptor | Thyrotropin-releasing hormone receptor (TRHR) | Protein | TRHR | Family A G protein-coupled receptor-like | Rhodopsin-like | Rhodopsin | ||||
| 26 | P37288, P47901 | G-Protein receptor | Vasopressin receptors (V1A,V1B) | Protein Family | AVPR1A, AVPR1B | Family A G protein-coupled receptor-like | Rhodopsin-like | Rhodopsin | ||||
| 27 | P16234, P09619 | Tyrosine-kinase-linked receptor | Platelet-derived growth factor receptors (PDGFRα, PDGFRβ) | Protein Family | PDGFRA, PDGFRB | Immunoglobulin | I set domains, V set domains (antibody variable domain-like) | Vascular cell adhesion molecule-1 (VCAM-1), Intercellular adhesion molecule-1, ICAM-1, Intercellular adhesion molecule-2, ICAM-2, Neural cell adhesion molecule (NCAM), Mucosal addressin cell adhesion molecule-1 (MADCAM-1), Telokin, Cardiac myosin binding protein C, different domains, Titin, Twitchin, Type-1 interleukin-1 receptor, Fibroblast growth factor receptor, FGFR, Hemolin, Semaphorin 4d Ig-like domain, Axonin-1, Perlecan Ig3 domain, Junction adhesion molecule, JAM, C-terminal domain, Biliary glycoprotein C (CD66a, CEACAM1A[1,4]), C-terminal domain, Second domain of the Flt-1 receptor, Tyrosine-protein kinase receptor tyro3, second domain, High affinity nerve growth factor receptor TrkA, different domains, Ligand binding domain of trkB receptor, NT3 binding domain of trkC receptor, Fc gamma receptor ectodomain (CD32), IgE high affinity receptor alpha subunit, Ig alpha Fc receptor, FCARI (CD89), Killer cell inhibitory receptor, Ligand binding domain of lir-1 (ilt2), Ligand binding domain of NK receptor NKp46, The p40 domain of interleukin-12 (IL-12 beta chain), N-terminal domain, Interleukin-6 receptor alpha chain, N-terminal domain, CD3 gamma chain ectodomain fragment, CD3 epsilon chain ectodomain fragment, B and T lymphocyte attenuator, Btla, CD3 delta chain ectodomain fragment, Myosin-binding protein C, slow-type, Receptor-type tyrosine-protein phosphatase mu, Immunoglobulin light chain kappa variable domain, VL-kappa, Immunoglobulin light chain lambda variable domain, VL-lambda, Immunoglobulin heavy chain variable domain, VH, Camelid IG heavy chain variable domain, VHh, T-cell antigen receptor, Immunoreceptor CTLA-4 (CD152), N-terminal fragment, Myelin membrane adhesion molecule P0, Myelin oligodendrocyte glycoprotein (MOG), Coxsackie virus and adenovirus receptor (Car), domain 1, N-terminal domain of sialoadhesin, N-terminal domain of sialic acid binding Ig-like lectin 7 (SIGLEC-7, p75/AIRM1), NK cell activating receptor NKP44, TREM-1 (triggering receptor expressed on myeloid cells 1), CD4 V-set domains, CD2, first domain, CD2-binding domain of CD58, N-terminal domain, CD80, N-terminal domain, CD86 (b7-2), N-terminal domain, Junction adhesion molecule, JAM, N-terminal domain, Biliary glycoprotein C (CD66a, CEACAM1A[1,4]), N-terminal domain, Tyrosine-protein kinase receptor tyro3, N-terminal domain, Programmed cell death protein 1, PD1, extracellular domain, HSV glycoprotein D, Novel antigen receptor (against lysozyme), Novel antigen receptor 12Y-1, Novel antigen receptor 12Y-2, Polymeric-immunoglobulin receptor, PIGR, Alphaherpesvirus glycoprotein E | ||||
| 28 | P00533, P04626, P21860, Q15303 | Tyrosine-kinase-linked receptor | Epidermal growth factor receptors (ERBB1–4) | Protein Family | EGFR, ERBB2, ERBB3, ERBB4 | L domain-like | L domain | Type 1 insulin-like growth factor receptor extracellular domain, Receptor protein-tyrosine kinase Erbb-3 extracellular domain, EGF receptor extracellular domain, Protooncoprotein Her2 extracellular domain | ||||
| 29 | Transducers | G-Protein (Gqα, G11α, G14α, G16α) | Not sure about these? | |||||||||
| 30 | Transducers | G-Protein (Gβγ) | A dimer formation of two sub units of a G protein, this isn't very specific??? | |||||||||
| 31 | Q08116, P41220, P49798, O15492 | Transducers | Regulators of G-protein signalling (RGS1, RGS2, RGS4, RGS16) | Protein | RGS1, RGS2, RGS4, RGS16 | Regulator of G-protein signaling, RGS | Regulator of G-protein signaling, RGS | Regulator of G-protein signaling 4, RGS4, RGS9, RGS domain, Galpha interacting protein, GaIP, Axin RGS-homologous domain, p115RhoGEF, Pdz-RhoGEF RGS-like domain, G-protein coupled receptor kinase 2, N-terminal domain, Regulator of G-protein signaling 18, RGS18 | ||||
| 32 | Q9NQ66, Q00722, Q01970, Q15147 | Transducers | Phospholipase C (PLCβ1–4) | Protein Family | PLCB1, PLCB2, PLCB3, PLCB4 | EF-hand | EF-hand modules in multidomain proteins | Phosphoinositide-specific phospholipase C, isozyme D1 (PLC-D!), Dystrophin, Cbl, alpha-Actinin, Nucleobindin 1 (CALNUC), Diacylglycerol kinase alpha, N-terminal domain, DJ-1-binding protein, DJBP, Phosphoinositide-specific phospholipase C, isozyme D1 (PLC-D!), Nucleobindin 1 (CALNUC), Phosphoinositide-specific phospholipase C, isozyme D1 (PLC-D!), Nucleobindin 1 (CALNUC), Phosphoinositide-specific phospholipase C, isozyme D1 (PLC-D!), Nucleobindin 1 (CALNUC) | ||||
| 33 | P19174, P16885 | Transducers | Phospholipase C (PLCγ1, PLCγ2) | Protein Family | PLCG1, PLCG2 | EF-hand | Calmodulin-like, EF-hand modules in multidomain proteins | Troponin C, Sarcoplasmic calcium-binding protein, Calcium vector protein, Calcium-regulated photoprotein, Calerythrin, EHCABP, Calmodulin, Calmodulin-related protein NB-1 (CLP), Caltractin (centrin 2), Cdc4p, Myosin Light Chain Mlc1p, Myosin Essential Chain, Myosin Regulatory Chain, Calcineurin regulatory subunit (B-chain), Calcineurin B-like protein 2, Recoverin, Kchip1, Kv4 potassium channel-interacting protein, Frequenin (neuronal calcium sensor 1), Guanylate cyclase activating protein 2, GCAP-2, Neurocalcin, Calcium- and integrin-binding protein, CIB, Calcium-dependent protein kinase sk5 CLD, Calmodulin-related protein T21P5.17, Phosphoinositide-specific phospholipase C, isozyme D1 (PLC-D!), Dystrophin, Cbl, alpha-Actinin, Nucleobindin 1 (CALNUC), Diacylglycerol kinase alpha, N-terminal domain, DJ-1-binding protein, DJBP | ||||
| 34 | P51178, Q8N3E9, Q9BRC7 | Transducers | Phospholipase C (PLCδ1–4) | Protein Family | PLCD1, PLCD3, PLCD4 | EF-hand | EF-hand modules in multidomain proteins | Phosphoinositide-specific phospholipase C, isozyme D1 (PLC-D!), Dystrophin, Cbl, alpha-Actinin, Nucleobindin 1 (CALNUC), Diacylglycerol kinase alpha, N-terminal domain, DJ-1-binding protein, DJBP, Phosphoinositide-specific phospholipase C, isozyme D1 (PLC-D!), Nucleobindin 1 (CALNUC), Phosphoinositide-specific phospholipase C, isozyme D1 (PLC-D!), Nucleobindin 1 (CALNUC) | ||||
| 35 | Q9P212 | Transducers | Phospholipase C (PLCε) | Protein | PLCE1 | EF-hand | EF-hand modules in multidomain proteins | Phosphoinositide-specific phospholipase C, isozyme D1 (PLC-D!), Dystrophin, Cbl, alpha-Actinin, Nucleobindin 1 (CALNUC), Diacylglycerol kinase alpha, N-terminal domain, DJ-1-binding protein, DJBP | ||||
| 36 | Q86YW0 | Transducers | Phospholipase C (PLCζ) | Protein | PLCZ1 | EF-hand | EF-hand modules in multidomain proteins | Phosphoinositide-specific phospholipase C, isozyme D1 (PLC-D!), Dystrophin, Cbl, alpha-Actinin, Nucleobindin 1 (CALNUC), Diacylglycerol kinase alpha, N-terminal domain, DJ-1-binding protein, DJBP | ||||
| 37 | P28907 | Transducers | ADP ribosyl cyclase CD38 | Protein | CD38 | N-(deoxy)ribosyltransferase-like | ADP ribosyl cyclase-like | ADP ribosyl cyclase, Bone marror stromal cell antigen 1, BST-1/CD157 (ADP ribosyl cyclase-2) | ||||
| 38 | Q13698, Q13936, Q01668, O60840 | Voltage-operated channels | CaV1.1, CaV1.2, CaV1.3, CaV1.4 (L-type) | Protein Family | CACNA1S, CACNA1C, CACNA1D, CACNA1F | EF-hand, Isocitrate/Isopropylmalate dehydrogenase-like | Calmodulin-like, Monomeric isocitrate dehydrogenase, Calbindin D9K | Troponin C, Sarcoplasmic calcium-binding protein, Calcium vector protein, Calcium-regulated photoprotein, Calerythrin, EHCABP, Calmodulin, Calmodulin-related protein NB-1 (CLP), Caltractin (centrin 2), Cdc4p, Myosin Light Chain Mlc1p, Myosin Essential Chain, Myosin Regulatory Chain, Calcineurin regulatory subunit (B-chain), Calcineurin B-like protein 2, Recoverin, Kchip1, Kv4 potassium channel-interacting protein, Frequenin (neuronal calcium sensor 1), Guanylate cyclase activating protein 2, GCAP-2, Neurocalcin, Calcium- and integrin-binding protein, CIB, Calcium-dependent protein kinase sk5 CLD, Calmodulin-related protein T21P5.17, Calmodulin-related protein NB-1 (CLP), Caltractin (centrin 2), Calcineurin regulatory subunit (B-chain), Frequenin (neuronal calcium sensor 1), Monomeric isocitrate dehydrogenase, Calbindin D9K | ||||
| 39 | O00555 | Voltage-operated channels | CaV2.1 (P/Q-type) | Protein | CACNA1A | Voltage-gated potassium channels | Voltage-gated potassium channels | Potassium channel protein, Potassium channel-related protein MthK, Potassium channel KVAP, Inward rectifier potassium channel Kirbac1.1, Inward rectifier potassium channel kirbac3.1 | ||||
| 40 | Q00975 | Voltage-operated channels | CaV2.2 (N-type) | Protein | CACNA1B | Voltage-gated potassium channels | Voltage-gated potassium channels | Potassium channel protein, Potassium channel-related protein MthK, Potassium channel KVAP, Inward rectifier potassium channel Kirbac1.1, Inward rectifier potassium channel kirbac3.1 | ||||
| 41 | O43497, O95180, Q9P0X4 | Voltage-operated channels | CaV3.1, CaV3.2, CaV3.3 (T-type) | Protein Family | CACNA1G, CACNA1H, CACNA1I | PRTase-like, Voltage-gated potassium channels | Phosphoribosyltransferases (PRTases), Voltage-gated potassium channels | Xanthine-guanine PRTase (XPRTase), Hypoxanthine-guanine-xanthine PRTase, Glutamine PRPP amidotransferase, C-terminal domain, Hypoxanthine-guanine PRTase (HGPRTase), Hypoxanthine PRTase, Adenine PRTase, Orotate PRTase, Uracil PRTase, Upp, Pyrimidine operon regulator PyrR, Pur operon repressor (PurR), C-terminal domain, Putative phosphoribosyltransferase TT1426 (TTHA1462), Xanthine phosphoribosyltransferase, Putative phosphoribosyltransferase TTHA1613, Pprobable purine phosphoribosyltransferase PH0095, Potassium channel protein, Potassium channel-related protein MthK, Potassium channel KVAP, Inward rectifier potassium channel Kirbac1.1, Inward rectifier potassium channel kirbac3.1 | ||||
| 42 | Q15878 | Voltage-operated channels | CaV2.3 (R-type) | Protein | CACNA1E | Voltage-gated potassium channels | Voltage-gated potassium channels | Potassium channel protein, Potassium channel-related protein MthK, Potassium channel KVAP, Inward rectifier potassium channel Kirbac1.1, Inward rectifier potassium channel kirbac3.1 | ||||
| 43 | Q05586, Q12879, Q13224, Q14957, O15399 | Receptor-operated channels | NMDA receptors (NR1, NR2A, NR2B, NR2C, NR2D) | Protein Family | GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D | Periplasmic binding protein-like I | L-arabinose binding protein-like | D-ribose-binding protein, L-arabinose-binding protein, D-allose-binding protein, Galactose/glucose-binding protein, Amide receptor/negative regulator of the amidase operon (AmiC), Quorum-sensing signal (autoinducer-2) binding protein LuxP, Purine repressor (PurR), C-terminal domain, Lac-repressor (lacR) core (C-terminal domain), Trehalose repressor, C-terminal domain, Leucine-,isoleucine-,valine-binding (LIV) protein, Leucine-binding protein, Hormone binding domain of the atrial natriuretic peptide receptor, Metabotropic glutamate receptor subtype 1, AI-2 receptor LsrB, Glucose-resistance amylase regulator CcpA, C-terminal domain, Amide receptor/negative regulator of the amidase operon (AmiC), Quorum-sensing signal (autoinducer-2) binding protein LuxP, Purine repressor (PurR), C-terminal domain, Lac-repressor (lacR) core (C-terminal domain), Leucine-,isoleucine-,valine-binding (LIV) protein, Amide receptor/negative regulator of the amidase operon (AmiC), Quorum-sensing signal (autoinducer-2) binding protein LuxP, Purine repressor (PurR), C-terminal domain, Lac-repressor (lacR) core (C-terminal domain), Leucine-,isoleucine-,valine-binding (LIV) protein, Amide receptor/negative regulator of the amidase operon (AmiC), Quorum-sensing signal (autoinducer-2) binding protein LuxP, Purine repressor (PurR), C-terminal domain, Lac-repressor (lacR) core (C-terminal domain), Leucine-,isoleucine-,valine-binding (LIV) protein, Amide receptor/negative regulator of the amidase operon (AmiC), Quorum-sensing signal (autoinducer-2) binding protein LuxP, Purine repressor (PurR), C-terminal domain, Lac-repressor (lacR) core (C-terminal domain), Leucine-,isoleucine-,valine-binding (LIV) protein | ||||
| 44 | Q99572 | Receptor-operated channels | ATP receptor (P2X7) | Protein | P2RX7 | p53-like transcription factors | Rel/Dorsal transcription factors, DNA-binding domain | T-cell transcription factor NFAT1 (NFATC), DNA-binding domain, T-cell transcription factor NFAT5 (TONEBP), DNA-binding domain, p50 subunit of NF-kappa B (NFKB), N-terminal domain, p52 subunit of NF-kappa B (NFKB), N-terminal domain, p65 subunit of NF-kappa B (NFKB), N-terminal domain, Dorsal homologue Gambif1 | ||||
| 45 | P02708, Q15822, P32297, P43681, P30532, Q15825, P36544, ?, Q9UGM1, Q9GZZ6 | P11230, P17787, Q05901, P30926 | Q07001 | Q04844 | P07510 | Receptor-operated channels | nACh receptor | Protein Family | CHRNA1, CHRNA2, CHRNA3, CHRNA4, CHRNA5, CHRNA6, CHRNA7, CHRNA8, CHRNA9, CHRNA10 | CHRNB1, CHRNB2, CHRNB3, CHRNB4 | CHRND | CHRNE | CHRNG | Nicotinic receptor ligand binding domain-like | Nicotinic receptor ligand binding domain-like | Acetylcholine binding protein (ACHBP), Acetylcholine binding protein (ACHBP), Acetylcholine binding protein (ACHBP), Acetylcholine binding protein (ACHBP), Acetylcholine binding protein (ACHBP), Acetylcholine binding protein (ACHBP), Acetylcholine binding protein (ACHBP), Acetylcholine binding protein (ACHBP), Acetylcholine binding protein (ACHBP), Acetylcholine binding protein (ACHBP), Acetylcholine binding protein (ACHBP), Acetylcholine binding protein (ACHBP), Acetylcholine binding protein (ACHBP), Acetylcholine binding protein (ACHBP), Acetylcholine binding protein (ACHBP), Acetylcholine binding protein (ACHBP) | ||||
| 46 | P29973, Q16280, Q16281, Q8IV77 | Q14028 | Q9NQW8 | Second-messenger-operated channels | Cyclic nucleotide gated channels (CNGA 1–4, CNGB 1, CNGB 3) | Protein Family | CNGA1, CNGA2, CNGA3, CNGA4, | CNGB1 | CNGB3 | cAMP-binding domain-like | cAMP-binding domain | Catabolite gene activator protein, N-terminal domain, CRP-like transcriptional regulator TM1171, N-terminal domain, Regulatory subunit of Protein kinase A, Regulatory domain of Epac2, domains 1 and 3, HCN pacemaker channel, Putative ion channel CnbD, Probable cyclic nucleotide-gated ion channel 6, Probable transcription regulator BT4300, N-terminal domain, Transcriptional regulator TTHA1359, N-terminal domain, Transcriptional regulator PG0396, N-terminal domain | ||||
| 47 | Second-messenger-operated channels | Arachidonate-regulated Ca2+ channel (IARC) | Can't work this one out, possibly IRC instead of IARC but doesn't help. | |||||||||
| 48 | P48995, Q6ZNB5, Q13507, Q9UBN4, Q9UL62, Q9Y210, Q9HCX4 | Transient receptor potential (TRP) ion-channels | TRPC1–7 | Protein Family | TRPC1, TRPC2, TRPC3, TRPC4, TRPC5, TRPC6, TRPC7 | Ankyrin repeat, Galactose-binding domain-like, ARM repeat | Ankyrin repeat, N-terminal domain of xrcc1, Mo25 protein | Ankyrin-R, 53BP2, GA bindinig protein (GABP) beta 1, Cell cycle inhibitor p19ink4D, p18ink4C(ink6), Cell cycle inhibitor p16ink4A, I-kappa-B-alpha, bcl-3, Transcription factor inhibitor I-kappa-B-beta, IKBB, Myotrophin, Swi6 ankyrin-repeat fragment, Pyk2-associated protein beta, Neurogenic locus notch receptor domain, 26S proteasome non-ATPase regulatory subunit 10, gankyrin, Myosin phosphatase targeting subunit 1, MYPT1, RNase L, 2-5a-dependent ribonuclease, N-terminal domain of xrcc1, Mo25 protein, GA bindinig protein (GABP) beta 1, p18ink4C(ink6), GA bindinig protein (GABP) beta 1, p18ink4C(ink6), GA bindinig protein (GABP) beta 1, p18ink4C(ink6) | ||||
| 49 | Q8NER1, Q9Y5S1, Q8NET8, Q9HBA0, Q9NQA5, Q9H1D0 | Transient receptor potential (TRP) ion-channels | TRPV1–6 | Protein Family | TRPV1, TRPV2, TRPV3, TRPV4, TRPV5, TRPV6 | Ankyrin repeat | Ankyrin repeat | Ankyrin-R, 53BP2, GA bindinig protein (GABP) beta 1, Cell cycle inhibitor p19ink4D, p18ink4C(ink6), Cell cycle inhibitor p16ink4A, I-kappa-B-alpha, bcl-3, Transcription factor inhibitor I-kappa-B-beta, IKBB, Myotrophin, Swi6 ankyrin-repeat fragment, Pyk2-associated protein beta, Neurogenic locus notch receptor domain, 26S proteasome non-ATPase regulatory subunit 10, gankyrin, Myosin phosphatase targeting subunit 1, MYPT1, RNase L, 2-5a-dependent ribonuclease, GA bindinig protein (GABP) beta 1, p18ink4C(ink6), GA bindinig protein (GABP) beta 1, p18ink4C(ink6), GA bindinig protein (GABP) beta 1, p18ink4C(ink6), GA bindinig protein (GABP) beta 1, p18ink4C(ink6), GA bindinig protein (GABP) beta 1, p18ink4C(ink6) | ||||
| 50 | Q7Z4N2, O94759, Q9HCF6, Q8TD43, Q9NZQ8, Q9BX84, Q96QT4, Q7Z2W7 | Transient receptor potential (TRP) ion-channels | TRPM1–8 | Protein Family | TRPM1, TRPM2, TRPM3, TRPM4, TRPM5, TRPM6, TRPM7, TRPM8 | Nudix, Coronavirus S2 glycoprotein, FAD/NAD(P)-binding domain, Retroviral matrix proteins, Protein kinase-like (PK-like), GCM domain | MutT-like, Coronavirus S2 glycoprotein, FAD/NAD-linked reductases, N-terminal and central domains, Immunodeficiency virus matrix proteins, MHCK/EF2 kinase, GCM domain | Nucleoside triphosphate pyrophosphorylase (MutT), Coenzyme A pyrophosphatase, ADP-ribose pyrophosphatase, ADP-ribose pyrophosphatase homologue YffH, ADP compounds hydrolase NudE, NUDT9 (mitochondrial ADP-ribose pyrophosphatase), 7,8-dihydro-8-oxoguanine triphosphatase Hmth1, Hypothetical protein DR1025, Diadenosine tetraphosphate hydrolase (Ap4A hydrolase), Hypothetical protein PAE3301, Hypothetical protein EF1141, AP6A hydrolase Ndx1, Hypothetical protein NE0184, Hypothetical protein SP1235 (spr1115), U8 snorna-binding protein x29, Diphosphoinositol polyphosphate phosphohydrolase, E2 spike glycoprotein, Glutathione reductase, Trypanothione reductase, Mammalian thioredoxin reductase, Apoptosis-inducing factor (AIF), Alkyl hydroperoxide reductase subunit F (AhpF), C-terminal domains, NADH peroxidase, NADH-dependent ferredoxin reductase, BphA4, Putidaredoxin reductase, Dihydrolipoamide dehydrogenase, NADH-dependent 2-ketopropyl coenzyme M oxidoreductase/carboxylase, Flavocytochrome c sulfide dehydrogenase, FCSD, flavin-binding subunit, Phenylacetone monooxygenase, NADH oxidase /nitrite reductase, Flavin-dependent monoxygenase SPBP16F5.08c, HIV-1 matrix protein (HIV-1 MA, HIVp17, p17, MA), SIV matrix antigen, Trp Ca-channel kinase domain, Mgcm1 | ||||
| 51 | Q9GZU1, Q8IZK6 | Transient receptor potential (TRP) ion-channels | TRPML (mucolipidin 1,2) | Protein Family | MCOLN1, MCOLN2 | Retrovirus capsid protein, N-terminal core domain, Voltage-gated potassium channels | Retrovirus capsid protein, N-terminal core domain, Voltage-gated potassium channels | HIV-1 capsid protein, EIAV capsid protein p26, HTLV-I capsid protein, RSV capsid protein, AKV capsid, Potassium channel protein, Potassium channel-related protein MthK, Potassium channel KVAP, Inward rectifier potassium channel Kirbac1.1, Inward rectifier potassium channel kirbac3.1 | ||||
| 52 | O75762 | Transient receptor potential (TRP) ion-channels | TRPNI (ANKTM1) | Protein | TRPA1 | Ankyrin repeat | Ankyrin repeat | Ankyrin-R, 53BP2, GA bindinig protein (GABP) beta 1, Cell cycle inhibitor p19ink4D, p18ink4C(ink6), Cell cycle inhibitor p16ink4A, I-kappa-B-alpha, bcl-3, Transcription factor inhibitor I-kappa-B-beta, IKBB, Myotrophin, Swi6 ankyrin-repeat fragment, Pyk2-associated protein beta, Neurogenic locus notch receptor domain, 26S proteasome non-ATPase regulatory subunit 10, gankyrin, Myosin phosphatase targeting subunit 1, MYPT1, RNase L, 2-5a-dependent ribonuclease | ||||
| 53 | Q14643 | Inositol-1,4,5-trisphophate receptors (Ins(1,4,5)P3Rs) | Ins(1,4,5)P3R1 | Protein | ITPR1 | ARM repeat | Armadillo repeat | beta-Catenin, Importin alpha, Importin beta, Karyopherin beta2, Karyopherin alpha, Exportin Cse1p | NM_002222 | |||
| 54 | Q14571 | Inositol-1,4,5-trisphophate receptors (Ins(1,4,5)P3Rs) | Ins(1,4,5)P3R2 | Protein | ITPR2 | ARM repeat | HspBP1 domain | Hsp70-binding protein 1 (HspBP1) | NM_002223 | |||
| 55 | Q14573 | Inositol-1,4,5-trisphophate receptors (Ins(1,4,5)P3Rs) | Ins(1,4,5)P3R3 | Protein | ITPR3 | Voltage-gated potassium channels | Voltage-gated potassium channels | Potassium channel protein, Potassium channel-related protein MthK, Potassium channel KVAP, Inward rectifier potassium channel Kirbac1.1, Inward rectifier potassium channel kirbac3.1 | NM_002224 | |||
| 56 | P21817, Q92736 | Ryanodine receptors (RYRs) | RYR1–3 | Protein Family | RYR1, RYR2 | EF-hand | Calmodulin-like | Troponin C, Sarcoplasmic calcium-binding protein, Calcium vector protein, Calcium-regulated photoprotein, Calerythrin, EHCABP, Calmodulin, Calmodulin-related protein NB-1 (CLP), Caltractin (centrin 2), Cdc4p, Myosin Light Chain Mlc1p, Myosin Essential Chain, Myosin Regulatory Chain, Calcineurin regulatory subunit (B-chain), Calcineurin B-like protein 2, Recoverin, Kchip1, Kv4 potassium channel-interacting protein, Frequenin (neuronal calcium sensor 1), Guanylate cyclase activating protein 2, GCAP-2, Neurocalcin, Calcium- and integrin-binding protein, CIB, Calcium-dependent protein kinase sk5 CLD, Calmodulin-related protein T21P5.17, Calmodulin-related protein NB-1 (CLP), Caltractin (centrin 2), Calcineurin regulatory subunit (B-chain), Frequenin (neuronal calcium sensor 1) | ||||
| 57 | P98161, Q13563 | Polycystins | PC1-2 | Protein Family | PKD1, PKD2 | PKD domain, EF-hand | PKD domain, Calmodulin-like | Polycystein-1, PKD-1, Surface layer protein, VPS10 domain-containing receptor SorCS2, Troponin C, Sarcoplasmic calcium-binding protein, Calcium vector protein, Calcium-regulated photoprotein, Calerythrin, EHCABP, Calmodulin, Calmodulin-related protein NB-1 (CLP), Caltractin (centrin 2), Cdc4p, Myosin Light Chain Mlc1p, Myosin Essential Chain, Myosin Regulatory Chain, Calcineurin regulatory subunit (B-chain), Calcineurin B-like protein 2, Recoverin, Kchip1, Kv4 potassium channel-interacting protein, Frequenin (neuronal calcium sensor 1), Guanylate cyclase activating protein 2, GCAP-2, Neurocalcin, Calcium- and integrin-binding protein, CIB, Calcium-dependent protein kinase sk5 CLD, Calmodulin-related protein T21P5.17 | ||||
| 58 | Q13061 | Channel regulators | Triadin | Protein | TRDN | NM_006073 | Associated with the release of Calcium ions from the sarcoplasmic reticulum. Mouse refseq id XM_483889. | |||||
| 59 | Q12797 | Channel regulators | Junctin | Protein Family | ASPH | TPR-like | Tetratricopeptide repeat (TPR) | Protein phosphatase 5, Hop, Vesicular transport protein sec17, Neutrophil cytosolic factor 2 (NCF-2, p67-phox), Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor), Cyclophilin 40, FKBP51, C-terminal domain, Hypothetical protein RSGI Ruh-001, Mitochondria fission protein Fis1, FKBP52 (FKBP4), C-terminal domain, O-GlcNAc transferase p110 subunit, OGT, Prolyl 4-hydroxylase alpha-1 subunit, P4HA1, Lipoprotein NlpI, STIP1 homology and U box-containing protein 1, STUB1, Mitochondrial import receptor subunit tom20-3, Putative 70 kda peptidylprolyl isomerase PFL2275c, SMG-7 | NM_004318 | Junctin, also called Aspartate beta-hydroxylase, thought to play an important role in calcium homeostasis. Alternative splicing of this gene results in five transcript variants which vary in protein translation, the coding of catalytic domains, and tissue expression. Forms a complex with triadin and ryanodine receptor found in cardiac muscle tissue. Mouse: refseq NM_023066, uniprot Q9EQ69 | ||
| 60 | P30626 | Channel regulators | Sorcin | Protein, Domain | SRI | EF-hand | Penta-EF-hand proteins | Apoptosis-linked protein alg-2, Sorcin, Grancalcin, Calpain small (regulatory) subunit (domain VI), Calpain large subunit, C-terminal domain (domain IV), Programmed cell death 6 protein-like protein | NM_003130 | EF-Hand domain, might be more interesting than the actual protein... | ||
| 61 | P62942 | Channel regulators | FKBP12 | Protein | FKBP12 | FKBP-like | FKBP immunophilin/proline isomerase | FK-506 binding protein (FKBP12), an immunophilin, Calcineurin (FKBP12.6), FKBP25, FKB-6, N-terminal domain, FKBP59-I, N-terminal domain, FKBP52, N-terminal domains, FKBP51, N-terminal domains, Mitotic rotamase PIN1, domain 2, Parvulin, Parvulin 10 (rotamase C), Archaeal FKBP, Macrophage infectivity potentiator protein (MIP), Peptidyl-prolyl cis-trans isomerase FkpA, Trigger factor PPIase domain, Porin chaperone SurA, PPIase domains, FKBP13 | NM_000801 | http://en.wikipedia.org/wiki/FKBP12 | ||
| 62 | Channel regulators | FKBP12.6 | Protein Isoform | FKBP12.6 | Novel isoform of FKBP12, which selectively binds to the cardiac ryanodine receptor http://www.rcsb.org/pdb/explore.do?structureId=1C9H | |||||||
| 63 | P26678 | Channel regulators | Phospholamban | Peptide | PLN | NM_002667 | Forms a pentamer tertiary structure (http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2hyn) from the peptide fragments (http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1fjk) in the membrane as part of a larger complex. | |||||
| 64 | Q9Y6F6 | Channel regulators | IRAG | Protein | MRVI1 | NM_006069 | Involved in complexes with Inositol-1,4,5-trisphophate receptors. | |||||
| 65 | O43865 | Channel regulators | IRBIT | Protein | AHCYL1 | NAD(P)-binding Rossmann-fold domains | Formate/glycerate dehydrogenases, NAD-domain | Formate dehydrogenase, Putative formate dehydrogenase, Transcription corepressor CtbP, D-2-hydroxyisocaproate dehydrogenase, D-glycerate dehydrogenase, Phosphoglycerate dehydrogenase, D-lactate dehydrogenase, L-alanine dehydrogenase, Nicotinamide nucleotide transhydrogenase dI component, S-adenosylhomocystein hydrolase | NM_006621 | |||
| 66 | P05937 | Cytosolic buffers | Calbindin D-28 | Protein | CALB1 | EF-hand | Calmodulin-like | Troponin C, Sarcoplasmic calcium-binding protein, Calcium vector protein, Calcium-regulated photoprotein, Calerythrin, EHCABP, Calmodulin, Calmodulin-related protein NB-1 (CLP), Caltractin (centrin 2), Cdc4p, Myosin Light Chain Mlc1p, Myosin Essential Chain, Myosin Regulatory Chain, Calcineurin regulatory subunit (B-chain), Calcineurin B-like protein 2, Recoverin, Kchip1, Kv4 potassium channel-interacting protein, Frequenin (neuronal calcium sensor 1), Guanylate cyclase activating protein 2, GCAP-2, Neurocalcin, Calcium- and integrin-binding protein, CIB, Calcium-dependent protein kinase sk5 CLD, Calmodulin-related protein T21P5.17 | NM_004929 | Calbindin-D9k has a similar role but there is no homology other than two EF-hands, and Calbindin-D28k has six. | ||
| 67 | P22676 | Cytosolic buffers | Calretinin | Protein | CALB2 | EF-hand | Calmodulin-like | Troponin C, Sarcoplasmic calcium-binding protein, Calcium vector protein, Calcium-regulated photoprotein, Calerythrin, EHCABP, Calmodulin, Calmodulin-related protein NB-1 (CLP), Caltractin (centrin 2), Cdc4p, Myosin Light Chain Mlc1p, Myosin Essential Chain, Myosin Regulatory Chain, Calcineurin regulatory subunit (B-chain), Calcineurin B-like protein 2, Recoverin, Kchip1, Kv4 potassium channel-interacting protein, Frequenin (neuronal calcium sensor 1), Guanylate cyclase activating protein 2, GCAP-2, Neurocalcin, Calcium- and integrin-binding protein, CIB, Calcium-dependent protein kinase sk5 CLD, Calmodulin-related protein T21P5.17 | NM_007088 | |||
| 68 | P20472 | Cytosolic buffers | Parvalbumin | Protein | PVALB | EF-hand | Parvalbumin | Oncomodulin, Parvalbumin | NM_002854 | |||
| 69 | P27824 | ER/SR buffers and chaperones | Calnexin | Protein | CANX | Concanavalin A-like lectins/glucanases | Calnexin/calreticulin | Calnexin | NM_001024649 | |||
| 70 | P27797 | ER/SR buffers and chaperones | Calreticulin | Protein | CALR | Concanavalin A-like lectins/glucanases | Calnexin/calreticulin | Calnexin | NM_004343 | |||
| 71 | P31415, O14958 | ER/SR buffers and chaperones | Calsequestrin | Protein, Domain | CASQ1, CASQ2 | Thioredoxin-like | Calsequestrin | Calsequestrin | NM_001231, NM_001232 | Calsequestrin domain looks to be more important than the protein in the calcium buffer function | ||
| 72 | P11021 | ER/SR buffers and chaperones | GRP 78 | Protein | HSPA5 | Actin-like ATPase domain | Actin/HSP70 | Heat shock protein 70kDa, ATPase fragment, Actin, Prokaryotic actin homolog MreB, Actin-related protein 3, Arp3, Actin-related protein 2, Arp2, Cell division protein FtsA, Plasmid segregation protein ParM | NM_005347 | Because so many ER proteins interact transiently with GRP78, it may play a key role in monitoring protein transport through the cell. | ||
| 73 | P14625 | ER/SR buffers and chaperones | GRP 94 | Protein | HSP90B1 | Ribosomal protein S5 domain 2-like | Hsp90 middle domain | Heat shock protein hsp82 | NM_003299 | Chaperone not sure what it has to do with Calcium, other than aiding in the formation of other calcium proteins in the ER? | ||
| 74 | P62158 | Ca2+-binding proteins | Calmodulin | Protein Family | CALM1-3 | EF-hand | Calmodulin-like | Troponin C, Sarcoplasmic calcium-binding protein, Calcium vector protein, Calcium-regulated photoprotein, Calerythrin, EHCABP, Calmodulin, Calmodulin-related protein NB-1 (CLP), Caltractin (centrin 2), Cdc4p, Myosin Light Chain Mlc1p, Myosin Essential Chain, Myosin Regulatory Chain, Calcineurin regulatory subunit (B-chain), Calcineurin B-like protein 2, Recoverin, Kchip1, Kv4 potassium channel-interacting protein, Frequenin (neuronal calcium sensor 1), Guanylate cyclase activating protein 2, GCAP-2, Neurocalcin, Calcium- and integrin-binding protein, CIB, Calcium-dependent protein kinase sk5 CLD, Calmodulin-related protein T21P5.17 | It contains four EF-hand motifs" | each of which binds a Ca2+ ion. The protein has two approximately symmetrical domains | separated by a flexible "hinge" region. " | |
| 75 | P63316 | Ca2+-binding proteins | Troponin C | Protein | TNNC1 | EF-hand | Calmodulin-like | Troponin C, Sarcoplasmic calcium-binding protein, Calcium vector protein, Calcium-regulated photoprotein, Calerythrin, EHCABP, Calmodulin, Calmodulin-related protein NB-1 (CLP), Caltractin (centrin 2), Cdc4p, Myosin Light Chain Mlc1p, Myosin Essential Chain, Myosin Regulatory Chain, Calcineurin regulatory subunit (B-chain), Calcineurin B-like protein 2, Recoverin, Kchip1, Kv4 potassium channel-interacting protein, Frequenin (neuronal calcium sensor 1), Guanylate cyclase activating protein 2, GCAP-2, Neurocalcin, Calcium- and integrin-binding protein, CIB, Calcium-dependent protein kinase sk5 CLD, Calmodulin-related protein T21P5.17 | NM_003280 | This is the Type 1 “slow” muscle protein. | ||
| 76 | P21579, Q8N9I0, Q9BQG1, Q9H2B2, O00445, Q5T7P8, O43581, Q8NBV8, Q86SS6, Q6XYQ8, Q9BT88, Q8IV01, Q7L8C5, Q8NB59, Q9BQS2, Q17RD7, Q9BSW7 | Ca2+-binding proteins | Synaptotagmin | Protein Family | SYT1-17 | C2 domain (Calcium/lipid-binding domain, CaLB), C2 domain (Calcium/lipid-binding domain, CaLB), C2 domain (Calcium/lipid-binding domain, CaLB), C2 domain (Calcium/lipid-binding domain, CaLB), C2 domain (Calcium/lipid-binding domain, CaLB), C2 domain (Calcium/lipid-binding domain, CaLB), C2 domain (Calcium/lipid-binding domain, CaLB), C2 domain (Calcium/lipid-binding domain, CaLB), C2 domain (Calcium/lipid-binding domain, CaLB), C2 domain (Calcium/lipid-binding domain, CaLB), C2 domain (Calcium/lipid-binding domain, CaLB), C2 domain (Calcium/lipid-binding domain, CaLB), C2 domain (Calcium/lipid-binding domain, CaLB), C2 domain (Calcium/lipid-binding domain, CaLB), C2 domain (Calcium/lipid-binding domain, CaLB), C2 domain (Calcium/lipid-binding domain, CaLB) | Synaptotagmin-like (S variant), Synaptotagmin-like (S variant), Synaptotagmin-like (S variant), Synaptotagmin-like (S variant), Synaptotagmin-like (S variant), Synaptotagmin-like (S variant), Synaptotagmin-like (S variant), Synaptotagmin-like (S variant), Synaptotagmin-like (S variant), Synaptotagmin-like (S variant), Synaptotagmin-like (S variant), Synaptotagmin-like (S variant), Synaptotagmin-like (S variant), Synaptotagmin-like (S variant), Synaptotagmin-like (S variant), Synaptotagmin-like (S variant) | Synaptogamin I, Synaptotagmin III, Synaptotagmin IV, Regulating synaptic membrane exocytosis protein, rim2, Piccolo, C2 domain from protein kinase c (alpha), C2 domain from protein kinase c (beta), C2b-domain of rabphilin, C2 domain protein At1g63220, Synaptotagmin XIII, C2 domain from protein kinase c (alpha), C2 domain from protein kinase c (beta), C2 domain from protein kinase c (alpha), C2 domain from protein kinase c (beta), C2 domain from protein kinase c (alpha), C2 domain from protein kinase c (beta), C2 domain from protein kinase c (alpha), C2 domain from protein kinase c (beta), C2 domain from protein kinase c (alpha), C2 domain from protein kinase c (beta), C2 domain from protein kinase c (alpha), C2 domain from protein kinase c (beta), C2 domain from protein kinase c (alpha), C2 domain from protein kinase c (beta), C2 domain from protein kinase c (alpha), C2 domain from protein kinase c (beta), C2 domain from protein kinase c (alpha), C2 domain from protein kinase c (beta), C2 domain from protein kinase c (alpha), C2 domain from protein kinase c (beta), C2 domain from protein kinase c (alpha), C2 domain from protein kinase c (beta), C2 domain from protein kinase c (alpha), C2 domain from protein kinase c (beta), C2 domain from protein kinase c (alpha), C2 domain from protein kinase c (beta), C2 domain from protein kinase c (alpha), C2 domain from protein kinase c (beta), C2 domain from protein kinase c (alpha), C2 domain from protein kinase c (beta) | C2A-B domains in all of these proteins bind Calcium. | |||
| 77 | P23297, P29034, P33764, P26447, P33763, P06703, P31151, P05109, P06702, P60903, P31949, P80511 | P04271 | P31949 | P25815 | Ca2+-binding proteins | S100A1–12, S100B, S100C, S100P | Protein Family | S100A1-12, S100B, S100P | EF-hand | S100 proteins | Calcyclin (S100), Calcyclin (S100), Calcyclin (S100), Calcyclin (S100), Calcyclin (S100), Calcyclin (S100), Calcyclin (S100), Calcyclin (S100), Calcyclin (S100), Calcyclin (S100), Calcyclin (S100), Calcyclin (S100), Calcyclin (S100), Calcyclin (S100), Calcyclin (S100) | S100C == S100A11 – Family are characterized as having two ef-hands and a low molecular weight. Most S100 proteins are homodimeric, consisting of two identical polypeptides held together by non-covalent bonds. Although S100 proteins are structurally similar to calmodulin, they differ in that they are cell-specific, expressed in particular cells at different levels depending on environmental factors. | |||
| 78 | P04083, P07355, P12429, Q6P452, P08758, P08133, P20073, P13928, O76027, Q9UJ72 | Ca2+-binding proteins | Annexin I–X | Protein Family | ANXA1-10 | Annexin | Annexin | Annexin I, Annexin III, Annexin IV, Annexin V, Annexin VI, Annexin XII, Plant annexin-like protein, Annexin GH1 | Annexin domain is what is important. | |||
| 79 | P62166 | Ca2+-binding proteins | Neuronal Ca2+ sensor family (NCS-1) | Protein | FREQ | EF-hand | Calmodulin-like | Troponin C, Sarcoplasmic calcium-binding protein, Calcium vector protein, Calcium-regulated photoprotein, Calerythrin, EHCABP, Calmodulin, Calmodulin-related protein NB-1 (CLP), Caltractin (centrin 2), Cdc4p, Myosin Light Chain Mlc1p, Myosin Essential Chain, Myosin Regulatory Chain, Calcineurin regulatory subunit (B-chain), Calcineurin B-like protein 2, Recoverin, Kchip1, Kv4 potassium channel-interacting protein, Frequenin (neuronal calcium sensor 1), Guanylate cyclase activating protein 2, GCAP-2, Neurocalcin, Calcium- and integrin-binding protein, CIB, Calcium-dependent protein kinase sk5 CLD, Calmodulin-related protein T21P5.17 | NM_014286 | Contains 4 EF-hand domains. | ||
| 80 | P62760, Q9UM19, P37235 | Ca2+-binding proteins | Visinin-like proteins (VILIP-1, VILIP-2, VILIP-3) | Protein Family | VSNL1, HPCAL4, HPCAL1 | EF-hand | Calmodulin-like | Troponin C, Sarcoplasmic calcium-binding protein, Calcium vector protein, Calcium-regulated photoprotein, Calerythrin, EHCABP, Calmodulin, Calmodulin-related protein NB-1 (CLP), Caltractin (centrin 2), Cdc4p, Myosin Light Chain Mlc1p, Myosin Essential Chain, Myosin Regulatory Chain, Calcineurin regulatory subunit (B-chain), Calcineurin B-like protein 2, Recoverin, Kchip1, Kv4 potassium channel-interacting protein, Frequenin (neuronal calcium sensor 1), Guanylate cyclase activating protein 2, GCAP-2, Neurocalcin, Calcium- and integrin-binding protein, CIB, Calcium-dependent protein kinase sk5 CLD, Calmodulin-related protein T21P5.17, Calmodulin-related protein NB-1 (CLP), Caltractin (centrin 2), Calcineurin regulatory subunit (B-chain), Frequenin (neuronal calcium sensor 1), Calmodulin-related protein NB-1 (CLP), Caltractin (centrin 2), Calcineurin regulatory subunit (B-chain), Frequenin (neuronal calcium sensor 1) | Two of these proteins appear to have been reclassified as Hippocalcin like? | |||
| 81 | P84074 | Ca2+-binding proteins | Hippocalcin | Protein | HPCA | EF-hand | Calmodulin-like | Troponin C, Sarcoplasmic calcium-binding protein, Calcium vector protein, Calcium-regulated photoprotein, Calerythrin, EHCABP, Calmodulin, Calmodulin-related protein NB-1 (CLP), Caltractin (centrin 2), Cdc4p, Myosin Light Chain Mlc1p, Myosin Essential Chain, Myosin Regulatory Chain, Calcineurin regulatory subunit (B-chain), Calcineurin B-like protein 2, Recoverin, Kchip1, Kv4 potassium channel-interacting protein, Frequenin (neuronal calcium sensor 1), Guanylate cyclase activating protein 2, GCAP-2, Neurocalcin, Calcium- and integrin-binding protein, CIB, Calcium-dependent protein kinase sk5 CLD, Calmodulin-related protein T21P5.17 | NM_002143 | This is part of the NCS family previously mentioned, some confusion here! | ||
| 82 | P35243 | Ca2+-binding proteins | Recoverin | Protein | RCVRN | EF-hand | Calmodulin-like | Troponin C, Sarcoplasmic calcium-binding protein, Calcium vector protein, Calcium-regulated photoprotein, Calerythrin, EHCABP, Calmodulin, Calmodulin-related protein NB-1 (CLP), Caltractin (centrin 2), Cdc4p, Myosin Light Chain Mlc1p, Myosin Essential Chain, Myosin Regulatory Chain, Calcineurin regulatory subunit (B-chain), Calcineurin B-like protein 2, Recoverin, Kchip1, Kv4 potassium channel-interacting protein, Frequenin (neuronal calcium sensor 1), Guanylate cyclase activating protein 2, GCAP-2, Neurocalcin, Calcium- and integrin-binding protein, CIB, Calcium-dependent protein kinase sk5 CLD, Calmodulin-related protein T21P5.17 | NM_002903 | Found in the eye inhibits rhodopsin kinase | ||
| 83 | Q9NZI2, Q9NS61, Q9Y2W7 | Ca2+-binding proteins | Kv-channel-interacting proteins (KchIP1–3) | Protein Family | KCNIP1-3 | EF-hand | Calmodulin-like | Troponin C, Sarcoplasmic calcium-binding protein, Calcium vector protein, Calcium-regulated photoprotein, Calerythrin, EHCABP, Calmodulin, Calmodulin-related protein NB-1 (CLP), Caltractin (centrin 2), Cdc4p, Myosin Light Chain Mlc1p, Myosin Essential Chain, Myosin Regulatory Chain, Calcineurin regulatory subunit (B-chain), Calcineurin B-like protein 2, Recoverin, Kchip1, Kv4 potassium channel-interacting protein, Frequenin (neuronal calcium sensor 1), Guanylate cyclase activating protein 2, GCAP-2, Neurocalcin, Calcium- and integrin-binding protein, CIB, Calcium-dependent protein kinase sk5 CLD, Calmodulin-related protein T21P5.17, Calmodulin-related protein NB-1 (CLP), Caltractin (centrin 2), Calcineurin regulatory subunit (B-chain), Frequenin (neuronal calcium sensor 1), Calmodulin-related protein NB-1 (CLP), Caltractin (centrin 2), Calcineurin regulatory subunit (B-chain), Frequenin (neuronal calcium sensor 1) | KCNIP3 aka Calsenilin | |||
| 84 | P43080, Q9UMX6, O95843 | Ca2+-binding proteins | Guanylate-cyclase-activating proteins (GCAP1–3) | Protein Family | GUCA1A, GUCA1B, GUCA1C | EF-hand | Calmodulin-like | Troponin C, Sarcoplasmic calcium-binding protein, Calcium vector protein, Calcium-regulated photoprotein, Calerythrin, EHCABP, Calmodulin, Calmodulin-related protein NB-1 (CLP), Caltractin (centrin 2), Cdc4p, Myosin Light Chain Mlc1p, Myosin Essential Chain, Myosin Regulatory Chain, Calcineurin regulatory subunit (B-chain), Calcineurin B-like protein 2, Recoverin, Kchip1, Kv4 potassium channel-interacting protein, Frequenin (neuronal calcium sensor 1), Guanylate cyclase activating protein 2, GCAP-2, Neurocalcin, Calcium- and integrin-binding protein, CIB, Calcium-dependent protein kinase sk5 CLD, Calmodulin-related protein T21P5.17, Calmodulin-related protein NB-1 (CLP), Caltractin (centrin 2), Calcineurin regulatory subunit (B-chain), Frequenin (neuronal calcium sensor 1), Calmodulin-related protein NB-1 (CLP), Caltractin (centrin 2), Calcineurin regulatory subunit (B-chain), Frequenin (neuronal calcium sensor 1) | ||||
| 85 | Q14012, Q8IU85, Q96NX5 | Q9UQM7, Q13554, Q13557, Q13555 | Q16566 | Ca2+-regulated enzymes | Ca2+/calmodulin-dependent protein kinases (CaMKI–IV) | Protein Family | CAMK1, CAMK1D, CAMK1G | CAMK2A, CAMK2B, CAMK2D, CAMK2G | CAMK4 | Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinase-like (PK-like), Caspase-like, NTF2-like, Protein kinase-like (PK-like) | Protein kinases, catalytic subunit, Caspase catalytic domain, Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A | Cyclin-dependent PK, CDK2, Cyclin-dependent PK, CDK5, Cyclin-dependent PK, CDK6, MAP kinase p38, MAP kinase p38-gamma, MAP kinase Erk2, c-jun N-terminal kinase (jnk3s), Glycogen synthase kinase-3 beta (Gsk3b), Protein kinase CK2, alpha subunit, Sky1p, cAMP-dependent PK, catalytic subunit, Pkb kinase (Akt-2), G-protein coupled receptor kinase 2, 3-phosphoinositide dependent protein kinase-1 Pdk1, Calmodulin-dependent protein kinase, Titin, kinase domain, Twitchin, kinase domain, Death-associated protein kinase, Dap, gamma-subunit of glycogen phosphorylase kinase (Phk), MAP kinase activated protein kinase 2, mapkap2, Cell cycle checkpoint kinase chk1, pak1, Mycobacterial protein kinase PknB, catalytic domain, Casein kinase-1, CK1, Aurora-related kinase 1 (aurora-2), B-Raf kinase, Type I TGF-beta receptor R4, c-src tyrosine kinase, Haemopoetic cell kinase Hck, Lymphocyte kinase (lck), Bruton's tyrosine kinase (Btk), Carboxyl-terminal src kinase (csk), Abelsone tyrosine kinase (abl), Musk tyrosine kinase, Focal adhesion kinase 1 (fak), EGF receptor tyrosine kinase, Erbb-1, ephb2 receptor tyrosine kinase, epha2 receptor tyrosine kinase, Tie2 kinase, Fibroblast growth factor receptor 1, Fibroblast growth factor receptor 2, Vascular endothelial growth factor receptor 2 (kdr), c-KIT receptor, Fl cytokine receptor, Insulin receptor, Insulin-like growth factor 1 receptor, Hepatocyte growth factor receptor, c-MET, Ribosomal protein S6 kinase alpha 5, Msk1, Tyrosine-protein kinase Itk/Tsk, Protein kinase wnk1, Tyrosine-protein kinase ZAP-70, Activated CDC42 kinase 1, ACK1, Mitogen-activated protein kinase 8 (jnk1), Serine/threonine protein kinase TAO2, Protein kinase C, theta type, Tyrosine-protein kinase SYK, Proto-oncogene serine/threonine-protein kinase Pim-1, Dual specificity mitogen-activated protein kinase kinase 2, Mek2, Dual specificity mitogen-activated protein kinase kinase 1, Mek1, Cell division protein kinase 7, CDK7, Serine/threonine-protein kinase Nek2, c-jun N-terminal kinase (jnk3s), Glycogen synthase kinase-3 beta (Gsk3b), Pkb kinase (Akt-2), gamma-subunit of glycogen phosphorylase kinase (Phk), Aurora-related kinase 1 (aurora-2), Lymphocyte kinase (lck), Bruton's tyrosine kinase (Btk), Carboxyl-terminal src kinase (csk), Abelsone tyrosine kinase (abl), Focal adhesion kinase 1 (fak), Vascular endothelial growth factor receptor 2 (kdr), Mitogen-activated protein kinase 8 (jnk1), c-jun N-terminal kinase (jnk3s), Glycogen synthase kinase-3 beta (Gsk3b), Pkb kinase (Akt-2), gamma-subunit of glycogen phosphorylase kinase (Phk), Aurora-related kinase 1 (aurora-2), Lymphocyte kinase (lck), Bruton's tyrosine kinase (Btk), Carboxyl-terminal src kinase (csk), Abelsone tyrosine kinase (abl), Focal adhesion kinase 1 (fak), Vascular endothelial growth factor receptor 2 (kdr), Mitogen-activated protein kinase 8 (jnk1), Apopain (caspase-3, cpp32), Interleukin-1beta converting enzyme (a cysteine protease), Caspase-1, Caspase-2, Caspase-7, Caspase-8, Caspase-9, Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A, c-jun N-terminal kinase (jnk3s), Glycogen synthase kinase-3 beta (Gsk3b), Pkb kinase (Akt-2), gamma-subunit of glycogen phosphorylase kinase (Phk), Aurora-related kinase 1 (aurora-2), Lymphocyte kinase (lck), Bruton's tyrosine kinase (Btk), Carboxyl-terminal src kinase (csk), Abelsone tyrosine kinase (abl), Focal adhesion kinase 1 (fak), Vascular endothelial growth factor receptor 2 (kdr), Mitogen-activated protein kinase 8 (jnk1) | CAMK3 is in Tobacco or Fungus not so sure this is relevant. These all appear to have alpha, beta, gamma, delta sub-units all presumably in a specific complex with calcium/calmodulin. | |||
| 86 | Q15746 | Ca2+-regulated enzymes | Myosin light chain kinase (MLCK) | Protein | MYLK | Immunoglobulin | I set domains | Vascular cell adhesion molecule-1 (VCAM-1), Intercellular adhesion molecule-1, ICAM-1, Intercellular adhesion molecule-2, ICAM-2, Neural cell adhesion molecule (NCAM), Mucosal addressin cell adhesion molecule-1 (MADCAM-1), Telokin, Cardiac myosin binding protein C, different domains, Titin, Twitchin, Type-1 interleukin-1 receptor, Fibroblast growth factor receptor, FGFR, Hemolin, Semaphorin 4d Ig-like domain, Axonin-1, Perlecan Ig3 domain, Junction adhesion molecule, JAM, C-terminal domain, Biliary glycoprotein C (CD66a, CEACAM1A[1,4]), C-terminal domain, Second domain of the Flt-1 receptor, Tyrosine-protein kinase receptor tyro3, second domain, High affinity nerve growth factor receptor TrkA, different domains, Ligand binding domain of trkB receptor, NT3 binding domain of trkC receptor, Fc gamma receptor ectodomain (CD32), IgE high affinity receptor alpha subunit, Ig alpha Fc receptor, FCARI (CD89), Killer cell inhibitory receptor, Ligand binding domain of lir-1 (ilt2), Ligand binding domain of NK receptor NKp46, The p40 domain of interleukin-12 (IL-12 beta chain), N-terminal domain, Interleukin-6 receptor alpha chain, N-terminal domain, CD3 gamma chain ectodomain fragment, CD3 epsilon chain ectodomain fragment, B and T lymphocyte attenuator, Btla, CD3 delta chain ectodomain fragment, Myosin-binding protein C, slow-type, Receptor-type tyrosine-protein phosphatase mu | Has a protein kinase domain and a load of imunoglobulin domains, think this is an indirect part of a calcium pathway. | |||
| 87 | P46020, P46019 | Q93100 | Q16816, P15735 | Ca2+-regulated enzymes | Phosphorylase kinase | Protein Family | PHKA1, PHKA2 | PHKB | PHKG1, PHKG2 | Six-hairpin glycosidases, Protein kinase-like (PK-like), Protein kinase-like (PK-like) | Bacterial glucoamylase C-terminal domain-like, Protein kinases, catalytic subunit | Bacterial glucoamylase, C-terminal domain, Glucodextranase, domain A, Cyclin-dependent PK, CDK2, Cyclin-dependent PK, CDK5, Cyclin-dependent PK, CDK6, MAP kinase p38, MAP kinase p38-gamma, MAP kinase Erk2, c-jun N-terminal kinase (jnk3s), Glycogen synthase kinase-3 beta (Gsk3b), Protein kinase CK2, alpha subunit, Sky1p, cAMP-dependent PK, catalytic subunit, Pkb kinase (Akt-2), G-protein coupled receptor kinase 2, 3-phosphoinositide dependent protein kinase-1 Pdk1, Calmodulin-dependent protein kinase, Titin, kinase domain, Twitchin, kinase domain, Death-associated protein kinase, Dap, gamma-subunit of glycogen phosphorylase kinase (Phk), MAP kinase activated protein kinase 2, mapkap2, Cell cycle checkpoint kinase chk1, pak1, Mycobacterial protein kinase PknB, catalytic domain, Casein kinase-1, CK1, Aurora-related kinase 1 (aurora-2), B-Raf kinase, Type I TGF-beta receptor R4, c-src tyrosine kinase, Haemopoetic cell kinase Hck, Lymphocyte kinase (lck), Bruton's tyrosine kinase (Btk), Carboxyl-terminal src kinase (csk), Abelsone tyrosine kinase (abl), Musk tyrosine kinase, Focal adhesion kinase 1 (fak), EGF receptor tyrosine kinase, Erbb-1, ephb2 receptor tyrosine kinase, epha2 receptor tyrosine kinase, Tie2 kinase, Fibroblast growth factor receptor 1, Fibroblast growth factor receptor 2, Vascular endothelial growth factor receptor 2 (kdr), c-KIT receptor, Fl cytokine receptor, Insulin receptor, Insulin-like growth factor 1 receptor, Hepatocyte growth factor receptor, c-MET, Ribosomal protein S6 kinase alpha 5, Msk1, Tyrosine-protein kinase Itk/Tsk, Protein kinase wnk1, Tyrosine-protein kinase ZAP-70, Activated CDC42 kinase 1, ACK1, Mitogen-activated protein kinase 8 (jnk1), Serine/threonine protein kinase TAO2, Protein kinase C, theta type, Tyrosine-protein kinase SYK, Proto-oncogene serine/threonine-protein kinase Pim-1, Dual specificity mitogen-activated protein kinase kinase 2, Mek2, Dual specificity mitogen-activated protein kinase kinase 1, Mek1, Cell division protein kinase 7, CDK7, Serine/threonine-protein kinase Nek2, c-jun N-terminal kinase (jnk3s), Glycogen synthase kinase-3 beta (Gsk3b), Pkb kinase (Akt-2), gamma-subunit of glycogen phosphorylase kinase (Phk), Aurora-related kinase 1 (aurora-2), Lymphocyte kinase (lck), Bruton's tyrosine kinase (Btk), Carboxyl-terminal src kinase (csk), Abelsone tyrosine kinase (abl), Focal adhesion kinase 1 (fak), Vascular endothelial growth factor receptor 2 (kdr), Mitogen-activated protein kinase 8 (jnk1) | Protein family that are just sub-units of a complex that converts glycogen phosphorylase b to glycogen phosphorylase a, activating it to release glucose-1-phosphate from glycogen. | |||
| 88 | P23677, P27987, Q96DU7 | Ca2+-regulated enzymes | Ins(1,4,5)P3 3-kinase | Protein Family | ITPKA, ITPKB, ITPKC | SAICAR synthase-like | Inositol polyphosphate kinase (IPK), Inositol polyphosphate kinase (IPK), Inositol polyphosphate kinase (IPK) | Inositol 1,4,5-trisphosphate 3-kinase A, IP3K A | Activated by calmodulin. | |||
| 89 | Q14289 | Ca2+-regulated enzymes | PYK2 | Protein | PTK2B | Second domain of FERM | Second domain of FERM | Moesin, Radixin, Ezrin, Erythroid membrane protein 4.1R, Merlin, Talin, Talin-1, Focal adhesion kinase 1 | ||||
| 90 | P17252, P05771, ??, P63318 | Ca2+-regulated enzymes | Protein kinase C (PKC-α, PKC-βI, PKC-βII, PKC-γ) | Protein Family | PRKCA, PRKCB, ?, PRKCG | C2 domain (Calcium/lipid-binding domain, CaLB), C2 domain (Calcium/lipid-binding domain, CaLB), C2 domain (Calcium/lipid-binding domain, CaLB) | Synaptotagmin-like (S variant), Synaptotagmin-like (S variant), Synaptotagmin-like (S variant) | Synaptogamin I, Synaptotagmin III, Synaptotagmin IV, Regulating synaptic membrane exocytosis protein, rim2, Piccolo, C2 domain from protein kinase c (alpha), C2 domain from protein kinase c (beta), C2b-domain of rabphilin, C2 domain protein At1g63220, Synaptotagmin XIII, C2 domain from protein kinase c (alpha), C2 domain from protein kinase c (beta), C2 domain from protein kinase c (alpha), C2 domain from protein kinase c (beta) | Confusing beta I and beta II not used anymore, epsilon type has a C2 domain so interacts with calcium but this is not in the list. | |||
| 91 | P54750, Q01064, Q14123 | Ca2+-regulated enzymes | Phosphodiesterase (PDE1A–C) | Protein Family | PDE1A, PDE1B, PDE1C | GRIP domain, HD-domain/PDEase-like | GRIP domain, PDEase | Golgi autoantigen, golgin-245, Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b, Catalytic domain of cyclic nucleotide phosphodiesterase pde4d, cGMP-specific 3',5'-cyclic phosphodiesterase pde5a1-Ibmx, cGMP-inhibited 3',5'-cyclic phosphodiesterase B, pde3b, High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, PDE9A, Catalytic domain of cyclic nucleotide phosphodiesterase 1b, PDE1B | ||||
| 92 | Q08828, O60266, P40145, O95622, O43306 | Ca2+-regulated enzymes | Adenylyl cyclase (AC-1, AC-III, AC-VIII, AC-V, AC-VI) | Protein Family | ADCY1, ADCY3, ADCY8, ADCY5, ADCY6 | Nucleotide cyclase, ERP29 C domain-like | Adenylyl and guanylyl cyclase catalytic domain, ERP29 C domain-like | Type II adenylyl cyclase C2 domain, Adenylyl cyclase VC1, domain C1a, Adenylyl cyclase IIC1, domain C2a, Receptor-type monomeric adenylyl cyclase, Adenylate cyclase CyaC, Endoplasmic reticulum protein ERP29, C-terminal domain, Windbeutel, C-terminal domain | ||||
| 93 | P29475, P35228, P29474 | Ca2+-regulated enzymes | Nitric oxide synthases, endothelial NOS (eNOS), neuronal NOS (nNOS) | Protein Family | NOS1, NOS2, NOS3 | PDZ domain-like, Flavoproteins | PDZ domain, Cytochrome p450 reductase N-terminal domain-like | Discs large protein homolog, Cask/Lin-2, Synapse-associated protein 102, Synaptic protein PSD-95, Syntrophin, Syntenin 1, Segment polarity protein dishevelled homolog Dvl-2, Neuronal nitric oxide synthase, NNOS, Phosphatase hPTP1e, Na+/H+ exchanger regulatory factor, NHERF, Inad, Glutamate receptor interacting protein, Erbin, GTPase-binding domain of the cell polarity protein par6 (Par-6B), Glutamate receptor-interacting protein 1, GRIP1, Membrane associated guanylate kinase inverted-2 (MAGI-2, KIAA0705), KIAA1526 protein, Hypothetical protein KIAA1095, Discs large 5 protein KIAA0583, Hypothetical protein KIAA0559, Hypothetical protein KIAA1849, Scribble (KIAA0147), Shank1, PDZ domain, Zasp (Cypher, Oracle 1), Alpha-actinin-2 associated LIM protein, Glutamate receptor interacting protein 2, GRIP2 (KIAA1719), Harmonin, Rhophilin-2, PDZ-LIM protein mystique, Enigma homolog ENH, DNA Regulating synaptic membrane exocytosis protein 2, RIMS2, Partitioning-defective 3-like protein, PAR3-L (RIKEN cDNA 2810455b10), Regulator of G-protein signaling 3, RGS3, PDZ domain containing protein 11, Pdzk11, hypothetical PDZ domain containing protein Uqcrc2 (4930408O21Rik), Tight junction protein ZO-2, Tjp2, Multiple PDZ domain protein, Afadin, Syntaxin binding protein 4, Channel associated protein of synapse-110, Maguk p55 subfamily member 5, Neurabin-i, Regulating synaptic membrane exocytosis protein 1, RIMS1, Amyloid beta A4 precursor protein-binding family A member 1 (APBA1, X11), Presynaptic protein sap97, Tyrosine-protein phosphatase non-receptor type 4, PTPN4, NADPH-cytochrome p450 reductase, N-terminal domain, Nitric oxide (NO) synthase FMN domain, Sulfite reductase alpha-component CysJ N-terminal domain, Nitric oxide (NO) synthase FMN domain | ||||
| 94 | Q08209, P16298, P48454 | Ca2+-regulated enzymes | Calcineurin | Protein Family | PPP3CA, PPP3CB, PPP3CC | Metallo-dependent phosphatases | Protein serine/threonine phosphatase | Protein phosphatase-1 (PP-1), Protein phosphatase-2B (PP-2B, calcineurin A subunit), lambda ser/thr protein phosphatase, Serine/threonine protein phosphatase 5, PP5, Protein phosphatase 2A catalytic subunit alpha isoform, PP2A-alpha, Protein phosphatase-1 (PP-1), Protein phosphatase-2B (PP-2B, calcineurin A subunit), Protein phosphatase-1 (PP-1), Protein phosphatase-2B (PP-2B, calcineurin A subunit) | Serine/threonine-protein phosphatase 2B catalytic subunit alpha, beta, gamma isoforms | |||
| 95 | P07384, P17655 | Ca2+-regulated enzymes | Ca2+-activated proteases (calpain I and II) | Protein Family | CAPN1, CAPN2 | EF-hand | Penta-EF-hand proteins | Apoptosis-linked protein alg-2, Sorcin, Grancalcin, Calpain small (regulatory) subunit (domain VI), Calpain large subunit, C-terminal domain (domain IV), Programmed cell death 6 protein-like protein, Calpain small (regulatory) subunit (domain VI), Calpain large subunit, C-terminal domain (domain IV) | Catalytic subunits | |||
| 96 | O95644, Q13469, Q12968, Q14934 | Transcription factors | Nuclear factor of activated T cells (NFATc1–4) | Protein Family | NFATC1, NFATC2, NFATC3, NFATC4 | p53-like transcription factors | Rel/Dorsal transcription factors, DNA-binding domain | T-cell transcription factor NFAT1 (NFATC), DNA-binding domain, T-cell transcription factor NFAT5 (TONEBP), DNA-binding domain, p50 subunit of NF-kappa B (NFKB), N-terminal domain, p52 subunit of NF-kappa B (NFKB), N-terminal domain, p65 subunit of NF-kappa B (NFKB), N-terminal domain, Dorsal homologue Gambif1, T-cell transcription factor NFAT1 (NFATC), DNA-binding domain, T-cell transcription factor NFAT5 (TONEBP), DNA-binding domain, p50 subunit of NF-kappa B (NFKB), N-terminal domain, p52 subunit of NF-kappa B (NFKB), N-terminal domain, p65 subunit of NF-kappa B (NFKB), N-terminal domain, T-cell transcription factor NFAT1 (NFATC), DNA-binding domain, T-cell transcription factor NFAT5 (TONEBP), DNA-binding domain, p50 subunit of NF-kappa B (NFKB), N-terminal domain, p52 subunit of NF-kappa B (NFKB), N-terminal domain, p65 subunit of NF-kappa B (NFKB), N-terminal domain, T-cell transcription factor NFAT1 (NFATC), DNA-binding domain, T-cell transcription factor NFAT5 (TONEBP), DNA-binding domain, p50 subunit of NF-kappa B (NFKB), N-terminal domain, p52 subunit of NF-kappa B (NFKB), N-terminal domain, p65 subunit of NF-kappa B (NFKB), N-terminal domain | ||||
| 97 | P16220, P15336, O43889, Q02930, Q96BA8, Q70SY1, Q68CJ9, Q8TEY5 | Transcription factors | Cyclic AMP response element-binding protein (CREB) | Protein Family | CREB1, ATF2, CREB3, CREB5, CREB3L1, CREB3L2, CREB3L3, CREB3L4 | Leucine zipper domain, Methylglyoxal synthase-like, A DNA-binding domain in eukaryotic transcription factors, C2H2 and C2HC zinc fingers | Leucine zipper domain, Methylglyoxal synthase, MgsA, A DNA-binding domain in eukaryotic transcription factors, Classic zinc finger, C2H2 | GCN4, CD2-Gal4, PPR1, PUT3, HAP1, PAP1, C-fos, C-jun, C-myc, Max, Transcription factor Creb, Atf4, C/ebp beta, C/ebp alpha, Cyclic-AMP-dependent transcription factor ATF-2, Trans-activator protein BZLF1, Methylglyoxal synthase, MgsA, Skn-1, Mafg, ZIF268, V(D)J recombination activating protein 1 (RAG1), dimerization domain, Tramtrack protein (two zinc-finger peptide), ADR1, XFIN, third domain, ZFY, SWI5 zinc-finger domains, Five-finger GLI1, Enhancer binding protein, Transcription factor sp1, Transactivation domain of cre-bp1/atf-2, Ying-yang 1 (yy1, zinc finger domain), Transcription factor IIIA, TFIIIA, GAGA factor, Kruppel-like factor 3, Bklf, Zinc finger protein ZFPM1 (FOG-1), Zinc finger protein 295, ZNF295, Wilms' tumor protein, WT1, Zinc finger protein 292, ZNF292, Zinc finger protein 512, ZNF512, Zinc finger protein 462, ZNF462, Zinc finger protein 692, ZNF692, Zinc fingers and homeoboxes protein 1, ZHX1, Zinc finger protein 24, Zinc finger protein 297b, GLI-Krueppel family member HKR3, Zinc finger protein 64, ZFP68, Zinc finger protein 593, ZNF593, Transcriptional repressor CTCF, Zinc finger and SCAN domain-containing protein 16, ZSCAN16 | ||||
| 98 | Q9Y2W7 | Transcription factors | Downstream regulatory element modulator (DREAM) | Protein | KCNIP3 | EF-hand | Calmodulin-like | Troponin C, Sarcoplasmic calcium-binding protein, Calcium vector protein, Calcium-regulated photoprotein, Calerythrin, EHCABP, Calmodulin, Calmodulin-related protein NB-1 (CLP), Caltractin (centrin 2), Cdc4p, Myosin Light Chain Mlc1p, Myosin Essential Chain, Myosin Regulatory Chain, Calcineurin regulatory subunit (B-chain), Calcineurin B-like protein 2, Recoverin, Kchip1, Kv4 potassium channel-interacting protein, Frequenin (neuronal calcium sensor 1), Guanylate cyclase activating protein 2, GCAP-2, Neurocalcin, Calcium- and integrin-binding protein, CIB, Calcium-dependent protein kinase sk5 CLD, Calmodulin-related protein T21P5.17 | Calsenilin (Kv channel-interacting protein 3) | |||
| 99 | Q92793 | Transcription factors | CREB-binding protein (CBP) | Protein | CREBBP | Kix domain of CBP (creb binding protein) | Kix domain of CBP (creb binding protein) | Kix domain of CBP (creb binding protein) | NM_001079846 | |||
| 100 | Q92952, Q9H2S1, Q9UGI6 | O15554 | Q12791, Q16558 | Ca2+-sensitive ion channels | Ca2+ activated potassium channels (SK small, IK large, BK large conductance) | Protein Family | KCNN1, KCNN2, KCNN3 | KCNN4 | KCNMA1, KCNMB1 | Voltage-gated potassium channels, NAD(P)-binding Rossmann-fold domains | Voltage-gated potassium channels, Potassium channel NAD-binding domain | Potassium channel protein, Potassium channel-related protein MthK, Potassium channel KVAP, Inward rectifier potassium channel Kirbac1.1, Inward rectifier potassium channel kirbac3.1, Rck domain from putative potassium channel Kch, Ktn bsu222, Ktn Mja218 | ||||
| 101 | A8K7I4 | Ca2+-sensitive ion channels | Human Cl– channel, Ca2+-activated (HCLCA1) | Protein | CLCA1 | Fibronectin type III | Fibronectin type III | Extracellular region of human tissue factor, Fibronectin, different Fn3 modules, Tenascin, Neuroglian, two amino proximal Fn3 repeats, Neural cell adhesion molecule 1, NCAM, Fibronectin type III domain from chitinase A1., Integrin beta-4 subunit, Growth hormone receptor, Erythropoietin (EPO) receptor, Prolactin receptor, Interleukin-4 receptor alpha chain, Common beta-chain in the GM-CSF, IL-3 and IL-5 receptors, Granulocyte colony-stimulating factor (GC-SF) receptor, Interferon-gamma receptor alpha chain, Cytokine receptor gp130 cytokine-binding domains, Interleukin-10 receptor 1, IL-10R1, Type I titin module, The p40 domain of interleukin-12 (IL-12 beta chain), domains 2 and 3, Interleukin-6 receptor alpha chain, domains 2 and 3, Interferon-alpha/beta receptor beta chain, KIAA1568 protein, KIAA0343 protein, KIAA1355, Ciliary neurotrophic factor receptor alpha, Host cell factor 2, HCF-2, Fibronectin type 3 and ankyrin repeat domains 1 protein, FANK1, Contactin 3 (KIAA1496), Fibronectin type-III domain containing protein 3a, FNDC3A (KIAA0970), Ephrin type-B receptor 1, Brother of CDO precursor (BOC), Ephrin type-A receptor 8, Cytokine receptor common gamma chain, Rim binding protein 2, Tenascin-X, Interleukin-2 receptor beta chain, Receptor-type tyrosine-protein phosphatase delta, PTPRD, Sidekick 2, Neogenin, Down syndrome cell adhesion molecule-like protein 1, DSCAML1, Myosin binding protein C, fast-type, Receptor-type tyrosine-protein phosphatase F, PTPRF, Hedgehog receptor iHog, Ephrin type-A receptor 1 | NM_001285 | |||
| 102 | P32418, Q9UPR5, P57103 | Na+/Ca2+ exchangers (NCXs) | NCX1–3 | Protein Family | SLC8A1, SLC8A2, SLC8A3 | CalX-like | CalX-beta domain | Sodium/calcium exchanger 1 | ||||
| 103 | O14983, P16615, Q93084 | Sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs) | SERCA1–3 | Protein Family | ATP2A1, ATP2A2, ATP2A3 | HAD-like | Meta-cation ATPase, catalytic domain P | Calcium ATPase, catalytic domain P, Cation-transporting ATPase | ||||
| 104 | P20020, Q01814, Q16720, P23634 | Plasma membrane Ca2+-ATPases (PMCAs) | PMCA1–4 | Protein Family | ATP2B1, ATP2B2, ATP2B3, ATP2B4 | HAD-like | Meta-cation ATPase, catalytic domain P | Calcium ATPase, catalytic domain P, Cation-transporting ATPase | ||||
| 105 | P98194, O75185 | Golgi pumps | SPCA1, SPCA2 | Protein Family | ATP2C1, ATP2C2 | HAD-like | Meta-cation ATPase, catalytic domain P | Calcium ATPase, catalytic domain P, Cation-transporting ATPase |
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